NLX-266 is a biased agonist of the serotonin 5-HT1A receptor. It acts specifically as a very-high-affinity and selective ERK1/2-biased serotonin 5-HT1A receptor agonist (Ki = 0.0447nM; EC50 = 0.437nM; Emax = 94%), with selectivity for ERK1/2 signaling over multiple other pathways.
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